神经节苷脂（Ganglioside）是一类含有唾液酸的酸性鞘糖脂，其分子由神经酰胺和连接有唾液酸残基的寡糖链构成。 1935年，德国化学家E. Klenk首次从泰萨二氏病（Tay-Sachs disease）患者脑组织中分 …

2026年3月1日 · In this case, a ganglioside transiently directs the molecular and biophysical organization of the membrane through orchestrating specific ganglioside-lipid and ganglioside-protein interactions.

2020年3月9日 · Ohkawa, Y. et al. Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains.

2026年5月29日 · The name ganglioside was first applied by the German scientist Ernst Klenk in 1942 to a mixture of complex glycosphingolipids newly isolated from ganglion cells of brain, but it was not …

They also do not bind proteins as strongly as their parental ganglioside molecules [38]. To overcome these issues, ganglioside-binding proteins, such as cholera toxin subunit B (CTB), are often used to …

Understanding the regulatory mechanisms governing ganglioside biosynthesis is essential for elucidating their roles in health and disease and may provide insights into therapeutic interventions …

2023年12月3日 · They also take part in the development and regeneration of neurons.25,26 During brain development, ganglio-side expression undergoes massive qualitative and quantitative …

2023年2月7日 · Ganglioside GD3 has an impact on immune regulation, including influencing the proliferation, activation, apoptosis, and biological functions of immune cells. It was reported that …

2020年10月6日 · In this review, we will summarize ganglioside functions that are crucial to maintain brain health, we will review changes in ganglioside levels that occur in major neurological conditions …

2025年9月17日 · For example, ganglioside GM1 synthesis is decreased in PD and HD, while loss-of-function mutations in ganglioside biosynthetic enzymes result in the lack of complex gangliosides in a …