蛋白酶体广泛分布于细胞质和细胞核中，26S蛋白酶体是一种分子量为2000的多亚基复合物，约有50种蛋白质亚基组成。具有多种蛋白水解酶活性，并且具有泛素依赖性。

The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to …

5 天之前 · The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

2 天之前 · Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.

泛素-蛋白酶体系统（Ubiquitin-Proteasome System, UPS）是真核细胞内负责蛋白质选择性降解的核心机制，通过控制细胞内约80%-90%的蛋白质降解，维持细胞内蛋白质代谢稳定。 [5] [7-8]

1 天前 · The ubiquitin-proteasome system (UPS) is a fundamental regulatory mechanism maintaining cellular proteostasis through the targeted degradation of proteins. Beyond its canonical role in protein …

2025年3月2日 · 泛素-蛋白酶体系统（ubiquitin-proteasome system, UPS） 在发现泛素-蛋白酶体系统之前，细胞中的蛋白质降解被认为主要依赖于溶酶体，一种膜包裹的囊状细胞器，内部为酸性环境且充 …

2026年3月18日 · Here we find that exhausted CD8+ T cells increase proteasome activity owing to the accumulation of depolarized mitochondria, which drives the selective degradation of mitochondrial …

2022年4月29日 · 蛋白酶体是蛋白质合成过程中错误折叠的蛋白质和其他蛋白质被蛋白酶解的主要降解途径。蛋白酶体抑制剂也被称为 蛋白酶抑制剂 是广泛用于癌症的辅助药物 。 蛋白酶体存在于所有真 …

The proteasome is part of the ubiquitin-proteasome system (UPS), which manages proteostasis in the cell. Via an UPS-specific enzymatic cascade, proteins become labelled with a small ubiquitin (Ub) tag.