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During the ovarian cycle gonadotropins produced by the anterior pituitary stimulate the development of ovarian structures called follicles. Estrogen production by the developing follicles increases estrogen concentrations in the blood. Increased estrogen concentrations initially inhibit gonadotropin release from the pituitary. As estrogen production continues to increase, concentrations reach a threshold level, resulting in the sudden release of gonadotropins and stimulating ovulation.1. The sti
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